Technical and Theoretic Limitations of the Experimental Evidence Supporting a Gut Bacterial Etiology in Mental Illness

    • Mayer E.A.
    • Tillisch K.
    • Gupta A.

    Gut/brain axis and the microbiota.

    J Clin Invest. 2015; 125: 926-938

    • Schloissnig S.
    • Arumugam M.
    • Sunagawa S.
    • et al.

    Genomic variation landscape of the human gut microbiome.

    Nature. 2013; 493: 45-50

    • Heintz-Buschart A.
    • Wilmes P.

    Human gut microbiome: function matters.

    Trends Microbiology. 2018; 26: 563-574

    • Sudo N.
    • Chida Y.
    • Aiba Y.
    • et al.

    Postnatal microbial colonization programs the hypothalamic–pituitary–adrenal system for stress response in mice.

    J Physiol. 2004; 558: 263-275

  • Psychobiotics: a new approach for treating mental illness?.

    Crit Rev Food Sci Nutr. 2019; 59: 1230-1236

    • Selhub E.M.
    • Logan A.C.
    • Bested A.C.

    Fermented foods, microbiota, and mental health: ancient practice meets nutritional psychiatry.

    J Physiol Anthropol. 2014; 33: 2https://doi.org/10.1186/1880-6805-33-2

    • Kelly J.R.
    • Borre Y.
    • O’Brien C.
    • et al.

    Transferring the blues: depression-associated gut microbiota induces neurobehavioural changes in the rat.

    J Psychiatr Res. 2016; 82: 109-118

    • Zheng P.
    • Zeng B.
    • Zhou C.
    • et al.

    Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism.

    Mol Psychiatry. 2016; 21: 786-796

    • Furness J.B.
    • Callaghan B.P.
    • Rivera L.R.
    • Cho H.J.

    The enteric nervous system and gastrointestinal innervation: integrated local and central control.

    in: Microbial Endocrinology: The Microbiota-Gut-Brain axis in Health and Disease. Springer,
    New York, NY2014: 39-71

  • The “biopsychosocial model”: 40 years of application in psychiatry.

    Psychiatrike. 2017; 28: 107-110

    • Yasuda K.
    • Oh K.
    • Ren B.
    • et al.

    Biogeography of the intestinal mucosal and luminal microbiome in the rhesus macaque.

    Cell host & microbe. 2015; 17: 385-391

    • Donaldson G.P.
    • Lee S.M.
    • Mazmanian S.K.

    Gut biogeography of the bacterial microbiota.

    Nat Rev Microbiol. 2016; 14: 20-32

    • Sender R.
    • Fuchs S.
    • Milo R.

    Revised estimates for the number of human and bacteria cells in the body.

    PLoS Biol. 2016; 14e1002533

  • Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism.

    Gut microbes. 2016; 7: 189-200

    • Naseribafrouei A.
    • Hestad K.
    • Avershina E.
    • et al.

    Correlation between the human fecal microbiota and depression.

    Neurogastroenterology Motil. 2014; 26: 1155-1162

  • Association between gut microbiota and autism spectrum disorder: a systematic review and meta-analysis.

    Front Psychiatry. 2019; 10: 473https://doi.org/10.3389/fpsyt.2019.00473

    • Nowakowski J.
    • Chrobak A.A.
    • Dudek D.

    Psychiatric illnesses in inflammatory bowel diseases-psychiatric comorbidity and biological underpinnings.

    Psychiatria polska. 2016; 50: 1157-1166

    • Jalanka J.
    • Hillamaa A.
    • Satokari R.
    • Mattila E.
    • Anttila V.J.
    • Arkkila P.

    The long-term effects of faecal microbiota transplantation for gastrointestinal symptoms and general health in patients with recurrent Clostridium difficile infection.

    Aliment Pharmacol Ther. 2018; 47: 371-379

    • Wood N.C.
    • Hamilton I.
    • Axon A.T.R.
    • et al.

    Abnormal intestinal permeability: an aetiological factor in chronic psychiatric disorders?.

    Br J Psychiatry. 1987; 150: 853-856

    • Leclercq S.
    • Matamoros S.
    • Cani P.D.
    • et al.

    Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity.

    Proc Natl Acad Sci. 2014; 111: E4485-E4493

    • Braniste V.
    • Al-Asmakh M.
    • Kowal C.
    • et al.

    The gut microbiota influences blood-brain barrier permeability in mice.

    Sci translational Med. 2014; 6 ()

    • Karczewski J.
    • Troost F.J.
    • Konings I.
    • et al.

    Regulation of human epithelial tight junction proteins by Lactobacillus plantarum in vivo and protective effects on the epithelial barrier.

    Am J physiology-gastrointestinal Liver Physiol. 2010; 298: G851-G859

    • Maes M.
    • Kubera M.
    • Leunis J.C.
    • Berk M.

    Increased IgA and IgM responses against gut commensals in chronic depression: further evidence for increased bacterial translocation or leaky gut.

    J affective Disord. 2012; 141: 55-62

    • Bron P.A.
    • Van Baarlen P.
    • Kleerebezem M.

    Emerging molecular insights into the interaction between probiotics and the host intestinal mucosa.

    Nat Rev Microbiol. 2012; 10: 66-78

    • Hsiao E.Y.
    • McBride S.W.
    • Hsien S.
    • et al.

    Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders.

    Cell. 2013; 155: 1451-1463

  • The high prevalence of poor physical health and unhealthy lifestyle behaviours in individuals with severe mental illness.

    Issues Ment Health Nurs. 2011; 32: 589-597

    • American Psychiatric Association

    Diagnostic and Statistical Manual of Mental Disorders (DSM-5®).

    American Psychiatric Pub,
    2013

    • David L.A.
    • Maurice C.F.
    • Carmody R.N.
    • et al.

    Diet rapidly and reproducibly alters the human gut microbiome.

    Nature. 2014; 505: 559

    • Monda V.
    • Villano I.
    • Messina A.
    • et al.

    Exercise modifies the gut microbiota with positive health effects.

    Oxidative Med Cell longevity. 2017; : 3831972

  • Use of germ-free animal models in microbiota-related research.

    J Microbiol Biotechnol. 2015; 25: 1583-1588

    • Heijtz R.D.
    • Wang S.
    • Anuar F.
    • et al.

    Normal gut microbiota modulates brain development and behavior.

    Proc Natl Acad Sci. 2011; 108: 3047-3052

  • Disruption of the gut ecosystem by antibiotics.

    Yonsei Med J. 2018; 59: 4-12

    • Lurie I.
    • Yang Y.X.
    • Haynes K.
    • Mamtani R.
    • Boursi B.

    Antibiotic exposure and the risk for depression, anxiety, or psychosis: a nested case-control study.

    J Clin Psychiatry. 2015; 76: 1522-1528

    • Lambrichts S.
    • Van Oudenhove L.
    • Sienaert P.

    Antibiotics and mania: a systematic review.

    J affective Disord. 2017; 219: 149-156

  • FDA updates warnings for fluoroquinolone antibiotics on risks of mental health and low blood sugar adverse reactions.

    Clin Infect Dis. 2018; 67 ()

    • Chaudhry I.B.
    • Hallak J.
    • Husain N.
    • et al.

    Minocycline benefits negative symptoms in early schizophrenia: a randomised double-blind placebo-controlled clinical trial in patients on standard treatment.

    J Psychopharmacol. 2012; 26: 1185-1193

    • Liu F.
    • Guo X.
    • Wu R.
    • et al.

    Minocycline supplementation for treatment of negative symptoms in early-phase schizophrenia: a double blind, randomized, controlled trial.

    Schizophrenia Res. 2014; 153: 169-176

    • Levkovitz Y.
    • Mendlovich S.
    • Riwkes S.
    • et al.

    A double-blind, randomized study of minocycline for the treatment of negative and cognitive symptoms in early-phase schizophrenia.

    J Clin Psychiatry. 2010; 71: 138-149

    • Deakin B.
    • Suckling J.
    • Barnes T.R.
    • et al.

    The benefit of minocycline on negative symptoms of schizophrenia in patients with recent-onset psychosis (BeneMin): a randomised, double-blind, placebo-controlled trial.

    The lancet psychiatry. 2018; 5: 885-894

    • Shibre T.
    • Alem A.
    • Abdulahi A.
    • et al.

    Trimethoprim as adjuvant treatment in schizophrenia: a double-blind, randomized, placebo-controlled clinical trial.

    Schizophrenia Bull. 2009; 36: 846-851

    • Zheng W.
    • Zhu X.M.
    • Zhang Q.E.
    • et al.

    Adjunctive minocycline for major mental disorders: a systematic review.

    J Psychopharmacol. 2019; 33: 1215-1226

    • Savitz J.B.
    • Teague T.K.
    • Misaki M.
    • et al.

    Treatment of bipolar depression with minocycline and/or aspirin: an adaptive, 2 × 2 double-blind, randomized, placebo-controlled, phase IIA clinical trial.

    Translational psychiatry. 2018; 8: 1-11

    • Bercik P.
    • Denou E.
    • Collins J.
    • et al.

    The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice.

    Gastroenterology. 2011; 141: 599-609

    • Brogden R.N.
    • Speight T.M.
    • Avery G.S.

    Minocycline: a review of its antibacterial and pharmacokinetic properties and therapeutic use.

    Drugs. 1975; 9: 251-291

    • Delungahawatta T.
    • Amin J.Y.
    • Stanisz A.M.
    • Bienenstock J.
    • Forsythe P.
    • Kunze W.A.

    Antibiotic driven changes in gut motility suggest direct modulation of enteric nervous system.

    Front Neurosci. 2017; 11: 588https://doi.org/10.3389/fnins.2017.00588

    • Champagne-Jorgensen K.
    • Kunze W.A.
    • Forsythe P.
    • Bienenstock J.
    • Neufeld K.A.M.

    Antibiotics and the nervous system: more than just the microbes?.

    Brain Behav Immun. 2019; 77: 7-15

    • McFarland L.V.
    • Evans C.T.
    • Goldstein E.J.

    Strain-specificity and disease-specificity of probiotic efficacy: a systematic review and meta-analysis.

    Front Med. 2018; 5: 124https://doi.org/10.3389/fmed.2018.00124

    • Hempel S.
    • Newberry S.
    • Ruelaz A.
    • et al.

    Safety of probiotics used to reduce risk and prevent or treat disease.

    Evid report/technology Assess. 2011; : 1-645

    • Ng Q.X.
    • Loke W.
    • Venkatanarayanan N.
    • Lim D.Y.
    • Soh A.Y.S.
    • Yeo W.S.

    A systematic review of the role of prebiotics and probiotics in autism spectrum disorders.

    Medicina. 2019; 55: 129https://doi.org/10.3390/medicina55050129

    • Parracho H.M.
    • Gibson G.R.
    • Knott F.
    • Bosscher D.
    • Kleerebezem M.
    • McCartney A.L.

    A double-blind, placebo-controlled, crossover-designed probiotic feeding study in children diagnosed with autistic spectrum disorders.

    Int J probiotics prebiotics. 2010; 5: 69-74

    • Slykerman R.F.
    • Kang J.
    • Van Zyl N.
    • et al.

    Effect of early probiotic supplementation on childhood cognition, behaviour and mood a randomised, placebo-controlled trial.

    Acta Paediatr. 2018; 107: 2172-2178

    • Ng Q.X.
    • Peters C.
    • Ho C.Y.X.
    • Lim D.Y.
    • Yeo W.S.

    A meta-analysis of the use of probiotics to alleviate depressive symptoms.

    J affective Disord. 2018; 228: 13-19

    • Liu B.
    • He Y.
    • Wang M.
    • et al.

    Efficacy of probiotics on anxiety—a meta-analysis of randomized controlled trials.

    Depress anxiety. 2018; 35: 935-945

    • Huang R.
    • Ning H.
    • Yang L.
    • et al.

    Efficacy of probiotics on anxiety: a meta-analysis of randomized controlled trials.

    Neuropsychiatry. 2017; 7: 862-871

    • McKean J.
    • Naug H.
    • Nikbakht E.
    • Amiet B.
    • Colson N.

    Probiotics and subclinical psychological symptoms in healthy participants: a systematic review and meta-analysis.

    J Altern Complement Med. 2017; 23: 249-258

    • Kristensen N.B.
    • Bryrup T.
    • Allin K.H.
    • Nielsen T.
    • Hansen T.H.
    • Pedersen O.

    Alterations in fecal microbiota composition by probiotic supplementation in healthy adults: a systematic review of randomized controlled trials.

    Genome Med. 2016; 8: 52https://doi.org/10.1186/s13073-016-0300-5

  • Ecological role of lactobacilli in the gastrointestinal tract: implications for fundamental and biomedical research.

    Appl Environ Microbiol. 2008; 74: 4985-4996

    • Li H.
    • Limenitakis J.P.
    • Fuhrer T.
    • et al.

    The outer mucus layer hosts a distinct intestinal microbial niche.

    Nat Commun. 2015; 6: 1-13

    • Smith N.W.
    • Shorten P.R.
    • Altermann E.
    • Roy N.C.
    • McNabb W.C.

    The classification and evolution of bacterial cross-feeding.

    Front Ecol Evol. 2019; 7: 153https://doi.org/10.3389/fevo.2019.00153

    • Kuleshov V.
    • Jiang C.
    • Zhou W.
    • Jahanbani F.
    • Batzoglou S.
    • Snyder M.

    Synthetic long-read sequencing reveals intraspecies diversity in the human microbiome.

    Nat Biotechnol. 2016; 34: 64-69

    • Brandt L.J.
    • Aroniadis O.C.
    • Mellow M.
    • et al.

    Long-term follow-up of colonoscopic fecal microbiota transplant for recurrent Clostridium difficile infection.

    Am J Gastroenterol. 2012; 107: 1079-1087

    • Gibbons R.J.
    • Socransky S.S.
    • Kapsimalis B.

    Establishment of human indigenous bacteria in germ-free mice.

    J Bacteriol. 1964; 88: 1316-1323

    • Walker E.A.
    • Katon W.J.
    • Jemelka R.P.
    • Roy-Byrne P.P.

    Comorbidity of gastrointestinal complaints, depression, and anxiety in the Epidemiologic Catchment Area (ECA) study.

    Am J Med. 1992; 92: S26-S30

    • Hillilä M.T.
    • Hämäläinen J.
    • Heikkinen M.E.
    • Färkkilä M.A.

    Gastrointestinal complaints among subjects with depressive symptoms in the general population.

    Aliment Pharmacol Ther. 2008; 28: 648-654

    • Kang D.W.
    • Adams J.B.
    • Coleman D.M.
    • et al.

    Long-term benefit of microbiota transfer therapy on autism symptoms and gut microbiota.

    Scientific Rep. 2019; 9: 5821

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